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Title: Effect of antiretroviral therapy on plasma concentrations of chloroquine and desethyl-chloroquine
Authors: Matthew M. Ippolito
Jeffrey M. Jacobson
Michael M. Lederman
Markus Winterberg
Joel Tarning
Theresa A. Shapiro
Charles Flexner
Temple University
Mahidol University
Nuffield Department of Clinical Medicine
Johns Hopkins Bloomberg School of Public Health
Johns Hopkins University
Case Western Reserve University
Keywords: Medicine
Issue Date: 30-Oct-2018
Citation: Clinical Infectious Diseases. Vol.67, No.10 (2018), 1617-1620
Abstract: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.
ISSN: 15376591
Appears in Collections:Scopus 2018

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