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Title: Outcome of newly diagnosed high risk medulloblastoma treated with carboplatin, vincristine, cyclophosphamide and etoposide
Authors: Nongnuch Sirachainan
Samart Pakakasama
Usanarat Anurathapan
Ake Hansasuta
Mantana Dhanachai
Chaiyos Khongkhatithum
Artit Jinawath
Pat Mahachoklertwattana
Suradej Hongeng
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Medicine;Neuroscience
Issue Date: 1-Oct-2018
Citation: Journal of Clinical Neuroscience. Vol.56, (2018), 139-142
Abstract: © 2018 Medulloblastoma is the most common malignant brain tumor among children. Although molecular study has been included in the new classification, in developing countries with limited resources the previous Chang staging system is still used. Therefore, treatment with postoperative radiation and chemotherapy remains the standard treatment. One common complication after treatment is ototoxicity, mainly due to radiation and cisplatinum. We report a revised chemotherapy protocol, replacing cisplatinum with carboplatin in newly diagnosed medulloblastoma cases. All 23 patients in this study had high risk medulloblastoma. Mean (SD) age was 9.5 ± 3.1 years. The 5-year progression free survival (PFS), 5-year overall survival (OS), and 10-year OS were 41.8 ± 12.2%, 60.0 ± 11.2%, and 48.0 ± 14.0 respectively. Most patients had grade 3–4 hematologic toxicity. Twelve patients had hearing tests, with 11 patients having grade 0 and 1 patient having grade 1 according to the Brock criteria.
ISSN: 15322653
Appears in Collections:Scopus 2018

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