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Title: The global burden of sepsis: Barriers and potential solutions
Authors: Kristina E. Rudd
Niranjan Kissoon
DIrek Limmathurotsakul
Sotharith Bory
Birungi Mutahunga
Christopher W. Seymour
Derek C. Angus
T. Eoin West
University of Washington, Seattle
Mahidol University
University of Pittsburgh Medical Center
The University of British Columbia
Nuffield Department of Clinical Medicine
University of Pittsburgh School of Medicine
Bwindi Community Hospital
Calmette Hospital
Keywords: Medicine
Issue Date: 23-Sep-2018
Citation: Critical Care. Vol.22, No.1 (2018), 123305059
Abstract: © 2018 The Author(s). Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.
ISSN: 1466609X
Appears in Collections:Scopus 2018

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