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Title: Nonalcoholic fatty liver disease and albuminuria: A systematic review and meta-analysis
Authors: Karn Wijarnpreecha
Charat Thongprayoon
Boonphiphop Boonpheng
Panadeekarn Panjawatanan
Konika Sharma
Patompong Ungprasert
Surakit Pungpapong
Wisit Cheungpasitporn
Faculty of Medicine, Siriraj Hospital, Mahidol University
University of Mississippi
Mayo Clinic in Jacksonville, Florida
East Tennessee State University
Chiang Mai University
Bassett Medical Center
Keywords: Medicine
Issue Date: 1-Sep-2018
Citation: European Journal of Gastroenterology and Hepatology. Vol.30, No.9 (2018), 986-994
Abstract: © 2018 Wolters Kluwer Health, Inc. All rights reserved. Background/objectives The relationship between nonalcoholic fatty liver disease (NAFLD) and albuminuria has been shown in many epidemiologic studies, although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of albuminuria among patients with NAFLD. Methods Comprehensive literature review was conducted utilizing Medline and Embase database through January 2018 to identify studies that compared the risk of albuminuria among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results Nineteen studies (17 cross-sectional studies and two cohort studies) with 24 804 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of albuminuria among patients with NAFLD was significantly higher than those without NAFLD with the pooled odds ratio (OR) of 1.67 [95% confidence interval (CI): 1.32-2.11]. Subgroup analysis demonstrated the significantly increased risk of albuminuria among patients with NAFLD without diabetes with pooled OR of 2.25 (95% CI: 1.65-3.06). However, we found no significant association between albuminuria and NAFLD among diabetic patients [pooled OR 1.28 (95% CI: 0.94-1.75)]. Conclusion A significantly increased risk of albuminuria among patients with NAFLD was observed in this meta-analysis. Physicians should pay more attention to the early detection and subsequent treatment of individuals with microalbuminuria especially in patients with NAFLD.
ISSN: 14735687
Appears in Collections:Scopus 2018

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