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Title: Aripiprazole for Irritability in Asian Children and Adolescents with Autistic Disorder: A 12-Week, Multinational, Multicenter, Prospective Open-Label Study
Authors: Hyo Won Kim
Eun Jin Park
Ji Hoon Kim
Vitharon Boon-Yasidhi
Jariya Tarugsa
Alexis Reyes
Stella Manalo
Yoo Sook Joung
University of the Philippines Manila
Philippine Children's Medical Center
Ulsan University
Inje University
Mahidol University
Pusan National University
Sungkyunkwan University
Keywords: Medicine
Issue Date: 1-Aug-2018
Citation: Journal of Child and Adolescent Psychopharmacology. Vol.28, No.6 (2018), 402-408
Abstract: © 2018, Mary Ann Liebert, Inc. Objectives: We investigated the effectiveness and tolerability of aripiprazole in the treatment of irritability in Asian children and adolescents (6-17 years) with autistic disorder in a 12-week, multinational, multicenter, open-label study. Methods: Sixty-seven subjects (10.0 ± 3.1 years old, 52 boys) were enrolled and treated with flexibly dosed aripiprazole for 12 weeks (mean dose, 5.1 ± 2.5 mg; range 2-15 mg). Results: Aripiprazole significantly reduced the mean caregiver-rated scores for the Irritability, Lethargy/Social Withdrawal, Stereotypy, Hyperactivity, and Inappropriate Speech subscales of the Aberrant Behavior Checklist from baseline to week 12 (p < 0.001 for all subscales). Clinician-rated Clinical Global Impression Severity of Illness scale score also improved from baseline through week 12 (p < 0.001). The most common adverse event was weight gain and no serious adverse event related to aripiprazole treatment was noted. Conclusion: Our results suggest that aripiprazole is effective and generally tolerable in the treatment of irritability in Asian children and adolescents with autistic disorder. Further studies with larger sample sizes and longer treatment durations are required.
ISSN: 15578992
Appears in Collections:Scopus 2018

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