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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/46495
Title: Seroprevalence of Hepatitis B Among HIV-infected Children and Adolescents Receiving Antiretroviral Therapy in the TREAT Asia Pediatric HIV Observational Database
Authors: Linda Aurpibul
Azar Kariminia
Ung Vibol
Moy Siew Fong
Oanh Ngoc Le
Rawiwan Hansudewechakul
Torsak Bunupuradah
Nia Kurniati
Kulkanya Chokephaibulkit
Nagalingeswaran Kumarasamy
Dewi Kumara Wati
Nik Khairulddin Nik Yusoff
Kamarul Azahar Mohd Razali
Revathy A. Nallusamy
Annette H. Sohn
Pagakrong Lumbiganon
VHS Medical Centre India
Universitas Udayana
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Kirby Institute
Kuala Lumpur Hospital
Khon Kaen University
The HIV Netherlands Australia Thailand Research Collaboration
Faculty of Medicine, Siriraj Hospital, Mahidol University
Chiang Mai University
Hospital Raja Perempuan Zainab II
Worldwide Orphans Foundation
University of Health Sciences
TREAT Asia/amfAR-The Foundation for AIDS Research
Chiangrai Prachanukroh Hospital
Hospital Likas
Penang Hospital
Keywords: Medicine
Issue Date: 1-Aug-2018
Citation: The Pediatric infectious disease journal. Vol.37, No.8 (2018), 788-793
Abstract: BACKGROUND: Hepatitis B (HBV)-HIV coinfection is associated with liver inflammation, which can progress to liver fibrosis/cirrhosis and hepatocellular carcinoma. We determined HBV seroprevalence in children and adolescents participating in the TREAT Asia Pediatric HIV Observational Database. METHODS: A multisite cross-sectional study was conducted in HIV-infected patients currently <25 years old receiving antiretroviral treatment (ART) who had HBV surface antigen (HBsAg), or HBV surface antibody (anti-HBs) or HBV core antibody (anti-HBc) tested during 2012-2013. HBV coinfection was defined as having either a positive HBsAg test or being anti-HBc positive and anti-HBs negative, reflective of past HBV infection. HBV seroprotection was defined as having a positive anti-HBs test. RESULTS: A total of 3380 patients from 6 countries (Vietnam, Thailand, Cambodia, Malaysia, Indonesia and India) were included. The current median (interquartile range) age was 11.2 (7.8-15.1) years. Of the 2755 patients (81.5%) with HBsAg testing, 130 (4.7%) were positive. Of 1558 (46%) with anti-HBc testing, 77 (4.9%) were positive. Thirteen of 1037 patients with all 3 tests were anti-HBc positive and HBsAg and anti-HBs negative. One child was positive for anti-HBc and negative for anti-HBs but did not have HBsAg tested. The prevalence of HBV coinfection was 144/2759 (5.2%) (95% confidence interval: 4.4-6.1). Of 1093 patients (32%) with anti-HBs testing, 257 (23.5%; confidence interval: 21.0-26.0) had positive tests representing HBV seroprotection. CONCLUSIONS: The estimated prevalence of HBV coinfection in this cohort of Asian HIV-infected children and adolescents on ART was 5.2%. The majority of children and adolescents tested in this cohort (76.5%) did not have protective HBV antibody. The finding supports HBV screening of HIV-infected children and adolescents to guide revaccination, the use of ART with anti-HBV activity and future monitoring.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061122587&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/46495
ISSN: 15320987
Appears in Collections:Scopus 2018

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