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Title: Prospective randomized, double-blinded, placebo-controlled trial of preoperative acetaminophen/tramadol for pain relief in manual vacuum aspiration under paracervical block
Authors: Wanchat Komon
Nathpong Israngura
Sakda Arj Ong Vallibhakara
Chonthicha Satirapod
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Medicine
Issue Date: 1-Jun-2018
Citation: Journal of the Medical Association of Thailand. Vol.101, No.6 (2018), 759-763
Abstract: © 2018, Medical Association of Thailand. All rights reserved. Objective: To evaluate the analgesic efficacy of pre-operative administration of acetaminophen/tramadol (Ultracet) when compared to placebo in patients undergoing uterine manual vacuum aspiration (MVA) under a standard technique of paracervical block. Materials and Methods: This double-blinded, randomized, concealed allocation, placebo-controlled trial enrolled 220 women who underwent MVA under a standard technique of paracervical block. One hundred and ten women were randomly assigned to receive ultracet and the others to placebo. The primary outcome was to assess the intensity of pain after procedure in term of visual analog pain score. Student’s t-tests and Chi-squared test were used to analyze data as proper. Results: No statistically significant differences in basic characteristics were observed in both groups of patients. The number of patients who had no pain (pain score=0) after MVA were significant increase in Ultracet group (P<0.01). In patients who still reported of pain, there was also lowered in pain intensity in Ultracet group. Only a few minor adverse effect was observed during the study. However this adverse effect showed no significant differences between groups. Conclusion: We concluded that the addition of the preoperative administration of acetaminophen/tramadol confirmed its efficacy to prevent pain in patients who undergo MVA under a standard technique of paracervical block.
ISSN: 01252208
Appears in Collections:Scopus 2018

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