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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/46616
Title: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphism as a genetic marker of cerebral malaria in Thai population
Authors: Saw Wah
Hathairad Hananantachai
Jintana Patarapotikul
Jun Ohashi
Izumi Naka
Pornlada Nuchnoi
University of Tokyo
Mahidol University
University of Medical Technology
Keywords: Medicine
Issue Date: 1-Jun-2018
Citation: Asian Pacific Journal of Tropical Medicine. Vol.11, No.6 (2018), 376-380
Abstract: © 2018 Medknow Publications. All rights reserved. Objective: To know whether the effect of interferon-induced protein with tetratricopeptide repeats (IFIT) 1 polymorphism influences the susceptibility of cerebral malaria outcome. Methods: Case-control association study was performed among 314 Thai patients (110 with cerebral malaria and 204 with uncomplicated malaria) infected with Plasmodium falciparum. Genotyping for five tag-single nucleotide polymorphisms of IFIT1 was performed by endpoint genotyping. Results: Genotype frequencies of all tag-SNPs (single nucleotide polymorphisms) showed no association with malaria outcome. However, C allele of rs11203109 was associated with the protection from cerebral malaria (OR=0.62, 95% CI=0.38-0.99, P=0.048). Two single nucleotide polymorphisms (rs5786868 and rs57941432) were in linkage disequilibrium with rs11203109. Conclusions: This suggests that our associated single nucleotide polymorphism (rs11203109) might be a genetic marker of cerebral malaria progression in the Thai population. http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=6;spage=376;epage=380;aulast=Wah;type=2.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049171879&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/46616
ISSN: 19957645
Appears in Collections:Scopus 2018

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