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Title: Tumor Contact Surface Area As a Predictor of Functional Outcomes After Standard Partial Nephrectomy: Utility and Limitations
Authors: Chalairat Suk-Ouichai
Jitao Wu
Wen Dong
Hajime Tanaka
Yanbo Wang
J. J.H. Zhang
Elvis Caraballo
Erick Remer
Jianbo Li
Sudhir Isharwal
Steven C. Campbell
Yantai Yuhuangding Hospital
Sun Yat-Sen University
Cleveland Clinic Foundation
Faculty of Medicine, Siriraj Hospital, Mahidol University
Jilin University
Tokyo Medical and Dental University
Keywords: Medicine
Issue Date: 1-Jun-2018
Citation: Urology. Vol.116, (2018), 106-113
Abstract: © 2018 Elsevier Inc. Objective: To evaluate contact surface area (CSA) between the tumor and parenchyma as a predictor of ipsilateral parenchyma and function preserved after partial nephrectomy (PN). Previous studies suggested that CSA is a strong predictor of functional outcomes but the limitations of CSA have not been adequately explored. Patients and Methods: Four hundred nineteen patients managed with standard PN for solitary tumor with necessary studies to evaluate and analyze ipsilateral preoperative or postoperative parenchymal mass and function. Parenchymal mass and CSA were measured using contrast-enhanced computed tomography <2 months prior and 3-12months after PN. CSA was calculated: 2πrd, where r = radius and d = intraparenchymal depth. Pearson-correlation evaluated relationships between CSA and ipsilateral parenchymal mass or function preserved. Multivariable regression assessed predictors of function preserved. Conceptually, the CSA paradigm should function better for exophytic tumors than endophytic ones. Results: Median tumor size was 3.5 cm and R.E.N.A.L. was 8. Median global and ipsilateral glomerular filtration rate preserved were 89% and 79%, respectively. Median ipsilateral parenchymal mass preserved was 85% and significantly higher for exophytic masses (P =.001). Median CSA was 22.8 cm 2 and significantly less for exophytic masses (P =.02). CSA associated with both ipsilateral function and mass preserved (both P <.05), but the correlations were only modest (r = 0.25 and 0.36, respectively). On multivariable analysis, CSA associated with function preserved for exophytic masses (P =.01), but not for endophytic ones (P =.27). Conclusion: CSA associates with functional outcomes after standard PN, although the strength of the correlations was modest, unlike previous studies, and CSA was not an independent predictor for endophytic tumors. Further study will be required to evaluate the utility of CSA in various clinical settings.
ISSN: 15279995
Appears in Collections:Scopus 2018

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