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Title: Contribution to Malaria Transmission of Symptomatic and Asymptomatic Parasite Carriers in Cambodia
Authors: Amélie Vantaux
Reingsey Samreth
Eakpor Piv
Nimol Khim
Saorin Kim
Laura Berne
Sophy Chy
Dysoley Lek
Sovannaroth Siv
Walter R. Taylor
Didier Ménard
Institut Pasteur du Cambodge
University of Oxford
Mahidol University
Institut Pasteur, Paris
Xeno Cell Innovations
National Center for Parasitology
National Institute of Public Health
Keywords: Medicine
Issue Date: 23-Apr-2018
Citation: Journal of Infectious Diseases. Vol.217, No.10 (2018), 1561-1568
Abstract: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Background Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers. Methods Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential. Results By microscopy and real-time polymerase chain reaction, Plasmodium falciparum gametocyte prevalence rates were, respectively, 19.3% (n = 21/109) and 44% (n = 47/109) on day (D) 0 and 17.9% (n = 5/28) and 89.3% (n = 25/28) in recrudescent patients (Drec) (RT-PCR Drec vs D0 P =.002). Falciparum malaria patient infectivity was low on D0 (6.2%; n = 3/48) and in Drec (8.3%; n = 1/12). Direct-membrane feeding assays and SFAs gave similar results. None of the falciparum (n = 0/19) and 3 of 28 Plasmodium vivax asymptomatic carriers were infectious to mosquitoes, including those that were followed up for 2 months. Overall, P. falciparum gametocytemias were low except in a few symptomatic carriers. Conclusions Only symptomatic falciparum malaria patients were infectious to mosquito vectors at baseline and recrudescence, highlighting the need to detect promptly and treat effectively P. falciparum patients.
ISSN: 15376613
Appears in Collections:Scopus 2018

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