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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/46819
Title: PRactice of VENTilation in Middle-Income Countries (PRoVENT-iMIC): Rationale and protocol for a prospective international multicentre observational study in intensive care units in Asia
Authors: Luigi Pisani
Anna Geke Algera
Ary Serpa Neto
Areef Ahsan
Abigail Beane
Kaweesak Chittawatanarat
Abul Faiz
Rashan Haniffa
Reza Hashemian
Madiha Hashmi
Hisham Ahmed Imad
Kanishka Indraratna
Shivakumar Iyer
Gyan Kayastha
Bhuvana Krishna
Hassan Moosa
Behzad Nadjm
Rajyabardhan Pattnaik
Sriram Sampath
Louise Thwaites
Ni Ni Tun
Nor'Azim Mohd Yunos
Salvatore Grasso
Frederique Paulus
Marcelo Gama De Abreu
Paolo Pelosi
Arjen M. Dondorp
Marcus J. Schultz
Ospedale Policlinico San Martino
Bharati Vidyapeeth Medical College, Pune
Sri Jayewardenepura General Hospital
Ispat General Hospital
The Aga Khan University
Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders
Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
Università degli Studi di Bari
Monash University Malaysia
Hospital Israelita Albert Einstein
Mahidol University
National Research Institute of Tuberculosis and Lung Disease Tehran
St. John's Medical College
Amsterdam UMC - University of Amsterdam
Chiang Mai University
Oxford University Clinical Research Unit
Medical Action Myanmar
Dev Care Foundation
Patan Academy of Health Sciences
Indira Gandhi Memorial Hospital
Oxford University Clinical Research Unit
Keywords: Medicine
Issue Date: 1-Apr-2018
Citation: BMJ Open. Vol.8, No.4 (2018)
Abstract: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction Current evidence on epidemiology and outcomes of invasively mechanically ventilated intensive care unit (ICU) patients is predominantly gathered in resource-rich settings. Patient casemix and patterns of critical illnesses, and probably also ventilation practices are likely to be different in resource-limited settings. We aim to investigate the epidemiological characteristics, ventilation practices and clinical outcomes of patients receiving mechanical ventilation in ICUs in Asia. Methods and analysis PRoVENT-iMIC (study of PRactice of VENTilation in Middle-Income Countries) is an international multicentre observational study to be undertaken in approximately 60 ICUs in 11 Asian countries. Consecutive patients aged 18 years or older who are receiving invasive ventilation in participating ICUs during a predefined 28-day period are to be enrolled, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cm H 2 O) during the first 3 days of mechanical ventilation - compared between patients at no risk for acute respiratory distress syndrome (ARDS), patients at risk for ARDS and in patients with ARDS (in case the diagnosis of ARDS can be made on admission). Secondary outcomes include occurrence of pulmonary complications and all-cause ICU mortality. Ethics and dissemination PRoVENT-iMIC will be the first international study that prospectively assesses ventilation practices, outcomes and epidemiology of invasively ventilated patients in ICUs in Asia. The results of this large study, to be disseminated through conference presentations and publications in international peer-reviewed journals, are of ultimate importance when designing trials of invasive ventilation in resource-limited ICUs. Access to source data will be made available through national or international anonymised datasets on request and after agreement of the PRoVENT-iMIC steering committee. Trial registration number NCT03188770; Pre-results.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057037600&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/46819
ISSN: 20446055
Appears in Collections:Scopus 2018

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