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Title: Research Directions in Genetic Predispositions to Stevens–Johnson Syndrome / Toxic Epidermal Necrolysis
Authors: Teri A. Manolio
Carolyn M. Hutter
Mark Avigan
Ricardo Cibotti
Robert L. Davis
Joshua C. Denny
Lois La Grenade
Lisa M. Wheatley
Mary N. Carrington
Wasun Chantratita
Wen Hung Chung
Andrea D. Dalton
Shuen Iu Hung
Ming Ta Michael Lee
J. Steven Leeder
Juan J.L. Lertora
Surakameth Mahasirimongkol
Howard L. McLeod
Maja Mockenhaupt
Michael Pacanowski
Elizabeth J. Phillips
Simone Pinheiro
Munir Pirmohamed
Cynthia Sung
Wimon Suwankesawong
Lauren Trepanier
Santa J. Tumminia
David Veenstra
Rika Yuliwulandari
Neil H. Shear
Leidos Inc.
National Yang-Ming University Taiwan
Chang Gung Memorial Hospital
Universität Freiburg im Breisgau
University of Wisconsin Madison, School of Veterinary Medicine
Massachusetts Institute of Technology
The Food and Drug Administration, Thailand Ministry of Public Health
University of Liverpool
Chang Gung University
Murdoch University
Children's Mercy Hospitals and Clinics
National Institute of Allergy and Infectious Diseases
National University of Singapore
University of Toronto
NIH Clinical Center
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Thailand Ministry of Public Health
University of Washington, Seattle
National Human Genome Research Institute
Food and Drug Administration
Geisinger Health System
National Eye Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Moffitt Cancer Center
Vanderbilt University
University of Tennessee Health Science Center
Stevens-Johnson Syndrome Foundation
YARSI University
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Mar-2018
Citation: Clinical Pharmacology and Therapeutics. Vol.103, No.3 (2018), 390-394
Abstract: © 2017 American Society for Clinical Pharmacology and Therapeutics Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.
ISSN: 15326535
Appears in Collections:Scopus 2018

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