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dc.contributor.authorKhie Chen Lieen_US
dc.contributor.authorChuen Yen Lauen_US
dc.contributor.authorNguyen Van Vinh Chauen_US
dc.contributor.authorT. Eoin Westen_US
dc.contributor.authorDirek Limmathurotsakulen_US
dc.contributor.authorPratiwi Sudarmonoen_US
dc.contributor.authorAbu Tholib Amanen_US
dc.contributor.authorMansyur Arifen_US
dc.contributor.authorArmaji Kamaludi Syarifen_US
dc.contributor.authorHerman Kosasihen_US
dc.contributor.authorMuhammad Karyanaen_US
dc.contributor.authorTawee Chotpitayasunondhen_US
dc.contributor.authorWarunee Punpanich Vandepitteen_US
dc.contributor.authorAdiratha Boonyasirien_US
dc.contributor.authorKeswadee Lapphraen_US
dc.contributor.authorKulkanya Chokephaibulkiten_US
dc.contributor.authorPinyo Rattanaumpawanen_US
dc.contributor.authorVisanu Thamlikitkulen_US
dc.contributor.authorAchara Laongnualpanichen_US
dc.contributor.authorPrapit Teparrakkulen_US
dc.contributor.authorPramot Srisamangen_US
dc.contributor.authorPhan Huu Phucen_US
dc.contributor.authorLe Thanh Haien_US
dc.contributor.authorNguyen Van Kinhen_US
dc.contributor.authorBui Duc Phuen_US
dc.contributor.authorNguyen Thanh Hungen_US
dc.contributor.authorTang Chi Thuongen_US
dc.contributor.authorHa Manh Tuanen_US
dc.contributor.authorLam Minh Yenen_US
dc.contributor.authorNguyen Van Vinh Chauen_US
dc.contributor.authorJanjira Thaipadungpaniten_US
dc.contributor.authorStuart Blacksellen_US
dc.contributor.authorNicholas Dayen_US
dc.contributor.authorClaire Lingen_US
dc.contributor.authorGuy Thwaitesen_US
dc.contributor.authorHeiman Wertheimen_US
dc.contributor.authorLe Van Tanen_US
dc.contributor.authorMotiur Rahmanen_US
dc.contributor.authorH. Rogier van Doornen_US
dc.contributor.otherSappasitthiprasong Hospitalen_US
dc.contributor.otherBadan Penelitian Dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesiaen_US
dc.contributor.otherUniversity of Indonesia, RSUPN Dr. Cipto Mangunkusumoen_US
dc.contributor.otherNational Institute of Allergy and Infectious Diseasesen_US
dc.contributor.otherUniversity of Washington, Seattleen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherQueen Sirikit National Institute of Child Healthen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherOxford University Clinical Research Uniten_US
dc.contributor.otherHue Central Hospitalen_US
dc.contributor.otherNational Hospital of Peadiatricsen_US
dc.contributor.otherWahidin Soedirohusodo Hospitalen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherChildren's Hospital 2en_US
dc.contributor.otherChildren's Hospital 1en_US
dc.contributor.otherSardjito Hospitalen_US
dc.contributor.otherNational Hospital of Tropical Diseasesen_US
dc.contributor.otherChiangrai Prachanukroh Hospitalen_US
dc.contributor.otherOxford University Clinical Research Uniten_US
dc.identifier.citationJournal of Intensive Care. Vol.6, No.1 (2018)en_US
dc.description.abstract© 2018 The Author(s). Background: Sepsis is a global threat but insufficiently studied in Southeast Asia. The objective was to evaluate management, outcomes, adherence to sepsis bundles, and mortality prediction of maximum Sequential Organ Failure Assessment (SOFA) scores in patients with community-acquired sepsis in Southeast Asia. Methods: We prospectively recruited hospitalized adults within 24 h of admission with community-acquired infection at nine public hospitals in Indonesia (n=3), Thailand (n=3), and Vietnam (n=3). In patients with organ dysfunction (total SOFA score ≥2), we analyzed sepsis management and outcomes and evaluated mortality prediction of the SOFA scores. Organ failure was defined as the maximum SOFA score ≥3 for an individual organ system. Results: From December 2013 to December 2015, 454 adult patients presenting with community-acquired sepsis due to diverse etiologies were enrolled. Compliance with sepsis bundles within 24 h of admission was low: broad-spectrum antibiotics in 76% (344/454), ≥1500 mL fluid in 50% of patients with hypotension or lactate ≥4 mmol/L (115/231), and adrenergic agents in 71% of patients with hypotension (135/191). Three hundred and fifty-five patients (78%) were managed outside of ICUs. Ninety-nine patients (22%) died. Total SOFA score on admission of those who subsequently died was significantly higher than that of those who survived (6.7 vs. 4.6, p<0.001). The number of organ failures showed a significant correlation with 28-day mortality, which ranged from 7% in patients without any organ failure to 47% in those with failure of at least four organs (p<0.001). The area under the receiver operating characteristic curve of the total SOFA score for discrimination of mortality was 0.68 (95% CI 0.62-0.74). Conclusions: Community-acquired sepsis in Southeast Asia due to a variety of pathogens is usually managed outside the ICU and with poor compliance to sepsis bundles. In this population, calculation of SOFA scores is feasible and SOFA scores are associated with mortality.en_US
dc.rightsMahidol Universityen_US
dc.titleUtility of SOFA score, management and outcomes of sepsis in Southeast Asia: A multinational multicenter prospective observational studyen_US
Appears in Collections:Scopus 2018

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