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Title: Taenia solium, Taenia saginata, Taenia asiatica, their hybrids and other helminthic infections occurring in a neglected tropical diseases' highly endemic area in Lao PDR
Authors: Marcello Otake Sato
Megumi Sato
Tetsuya Yanagida
Jitra Waikagul
Tiengkham Pongvongsa
Yasuhito Sako
Surapol Sanguankiat
Tipparayat Yoonuan
Sengchanh Kounnavang
Satoru Kawai
Akira Ito
Munehiro Okamoto
Kazuhiko Moji
Niigata University
Yamaguchi University
Mahidol University
Nagasaki University
Kyoto University
Asahikawa Medical University
Dokkyo Medical University
Station of Malariology
Ministry of Health
Keywords: Medicine
Issue Date: 8-Feb-2018
Citation: PLoS Neglected Tropical Diseases. Vol.12, No.2 (2018)
Abstract: © 2018 Sato et al. Most part of Southeast Asia is considered endemic for human-infecting Taenia tapeworms; Taenia solium, T. saginata, and T. asiatica. However, until now there was no report of the occurrence of human cases of T. asiatica in Lao PDR. This study, conducted in Savannakhet Province, Lao PDR, microscopically examined a total of 470 fecal samples by Kato Katz method and found 86% of people harboring at least one helminth. Hookworms were detected in 56% of the samples besides Opisthorchis like eggs (42%), Trichuris trichiura (27%), Ascaris spp. (14%), and Taenia spp. (4%) eggs. Serology for cysticercosis showed 6.8% positives with results varying from 3% to 14.3% in Ethnic School students and Kalouk Kao village respectively. Species-specific PCR targeting mitochondrial DNA (mtDNA) of 28 tapeworms, recovered from 16 patients, revealed T. solium (n = 2), T. saginata (n = 21), and T. asiatica (n = 5). Two patients were confirmed to be coinfected with T. saginata and T. asiatica, indicating the endemicity of the 3 human Taenia in Lao PDR. However, nucleotide sequencing of a nuclear DNA gene, DNA polymerase delta (pold) revealed that all the tapeworms identified as T. asiatica using mtDNA had T. saginata type allele at pold locus, demonstrating that they are not “pure T. asiatica” but the hybrid descendants between the two species, confirming the wide distribution of hybrids of T. saginata/ T. asiatica in Southeast Asia. The high prevalence of several helminthic NTDs in east Savannakhet area even with conventional control measures indicates the importance to establish wide and multifaceted health programs to sustainably improve the quality of life of the populations living in these communities.
ISSN: 19352735
Appears in Collections:Scopus 2018

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