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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/47192
Title: Evaluation of Autonomic Nervous System, Saliva Cortisol Levels, and Cognitive Function in Major Depressive Disorder Patients
Authors: Sukonthar Ngampramuan
Puttichai Tungtong
Sujira Mukda
Apichat Jariyavilas
Chanin Sakulisariyaporn
Srithanya Hospital
Mahidol University
Srinakharinwirot University
Keywords: Medicine;Psychology
Issue Date: 1-Jan-2018
Citation: Depression Research and Treatment. Vol.2018, (2018)
Abstract: © 2018 Sukonthar Ngampramuan et al. Major depressive disorder (MDD) is associated with changes in autonomic nervous system (ANS) and cognitive impairment. Heart rate variability (HRV) and Pulse pressure (PP) parameters reflect influences of the sympathetic and parasympathetic nervous system. Cortisol exerts its greatest effect on the hippocampus, a brain area closely related to cognitive function. This study aims to examine the effect of HRV, PPG, salivary cortisol levels, and cognitive function in MDD patients by using noninvasive techniques. We have recruited MDD patients, diagnosed based on DSM-V-TR criteria compared with healthy control subjects. Their HRV and PP were measured by electrocardiogram (ECG) and photoplethysmography (PPG). Salivary cortisol levels were collected and measured on the same day. MDD patients exhibited elevated values of mean HR, standard deviation of HR (SDHR), low frequency (LF) power, low frequency/high frequency (LF/HF) ratio, mean PP, standard deviation of pulse pressure (SDPP), and salivary cortisol levels. Simultaneously, they displayed lower values of mean of R-R intervals (mean NN), standard deviation of R-R intervals (SDNN), high frequency (HF) power, and WCST scores. Results have shown that the ANS of MDD patients were dominated by the sympathetic activity and that they have cognitive deficits especially in the domain of executive functioning.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045690070&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/47192
ISSN: 2090133X
20901321
Appears in Collections:Scopus 2018

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