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Title: Prospective research on infants with mild encephalopathy: The PRIME study
Authors: C. Prempunpong
L. F. Chalak
J. Garfinkle
B. Shah
V. Kalra
N. Rollins
R. Boyle
K. A. Nguyen
I. Mir
A. Pappas
P. Montaldo
S. Thayyil
P. J. Sánchez
S. Shankaran
A. R. Laptook
G. Sant'anna
UT Southwestern Medical Center
Imperial College London
Mahidol University
Brown University
Wayne State University
Centre universitaire de santé McGill
Ohio State University
Keywords: Medicine
Issue Date: 1-Jan-2018
Citation: Journal of Perinatology. Vol.38, No.1 (2018), 80-85
Abstract: © 2018 Nature America, Inc., part of Springer Nature. All rights reserved. Objective:To determine short-term outcomes of infants with evidence of hypoxia-ischemia at birth and classified as mild neonatal encephalopathy (NE) at <6 h of age.Study Design:Prospective multicenter study. Mild NE was defined as 3/41 abnormal category in modified Sarnat score. Primary outcome was any abnormality on early amplitude integrated electroencephalogram (aEEG) or seizures, abnormal brain magnetic resonance imaging (MRI) or neurological exam at discharge.Results:A total of 54/63 (86%) of enrolled infants had data on components of the primary outcome, which was abnormal in 28/54 (52%): discontinuous aEEG (n=4), MRI (n=9) and discharge exam (n=22). Abnormal tone and/or incomplete Moro were the most common findings. MRI abnormalities were confined to cerebral cortex but two infants had basal ganglia and/or thalamus involvement. The 18 to 24 months follow-up is ongoing.Conclusions:A larger than expected proportion of mild NE infants with abnormal outcomes was observed. Future research should evaluate safety and efficacy of neuroprotection for mild NE.
ISSN: 14765543
Appears in Collections:Scopus 2018

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