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Title: New ansamycins from the deep-sea-derived bacterium ochrobactrum sp. OUCMDZ-2164
Authors: Yaqin Fan
Cong Wang
Liping Wang
Arthit Chairoungdua
Pawinee Piyachaturawat
Peng Fu
Weiming Zhu
Guangxi University for Nationalities
Ocean University of China
Mahidol University
Guizhou Medical University
Qingdao National Laboratory for Marine Science and Technology
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-Aug-2018
Citation: Marine Drugs. Vol.16, No.8 (2018)
Abstract: © 2018 by the authors. All Rights Reserved. Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC 50 values of 15 and 23 µM, respectively.
ISSN: 16603397
Appears in Collections:Scopus 2018

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