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Title: Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp.
Authors: Shigeru Kitani
Mitsuki Yoshida
Ousana Boonlucksanawong
Watanalai Panbangred
Atchareeya Anuegoonpipat
Takeshi Kurosu
Kazuyoshi Ikuta
Yasuhiro Igarashi
Takuya Nihira
Toyama Prefectural University
National Institute of Infectious Diseases
Osaka University
Mahidol University
National Institutes of Health, Bethesda
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-2018
Citation: Journal of Antibiotics. Vol.71, No.7 (2018), 662-666
Abstract: © 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association. We identified a new cyclic lipodepsipeptide, cystargamide B (1), from the mycelial extract of a Kaempferia galanga rhizome-derived actinomycete strain, Streptomyces sp. PB013. The planar structure was elucidated based on high resolution fast-atom bombardment mass spectrometry (HRFABMS) spectroscopy and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic data. The absolute configurations of the constituent amino acids were determined using advanced Marfey's method. Cystargamide B (1) includes rare structural units: a 5-hydroxytryptophan residue and a 2,3-epoxy fatty acid side chain. Notably, cystargamide B (1) inhibited the protease activity of the NS2B/NS3 complex from dengue virus.
ISSN: 18811469
Appears in Collections:Scopus 2018

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