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dc.contributor.authorCong Wangen_US
dc.contributor.authorAdeep Mongeren_US
dc.contributor.authorLiping Wangen_US
dc.contributor.authorPeng Fuen_US
dc.contributor.authorPawinee Piyachaturawaten_US
dc.contributor.authorArthit Chairoungduaen_US
dc.contributor.authorWeiming Zhuen_US
dc.contributor.otherGuangxi University for Nationalitiesen_US
dc.contributor.otherOcean University of Chinaen_US
dc.contributor.otherChinese Academy of Sciencesen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherQingdao National Laboratory for Marine Science and Technologyen_US
dc.date.accessioned2019-08-28T06:51:39Z-
dc.date.available2019-08-28T06:51:39Z-
dc.date.issued2018-05-01en_US
dc.identifier.citationMarine Drugs. Vol.16, No.5 (2018)en_US
dc.identifier.issn16603397en_US
dc.identifier.other2-s2.0-85047176616en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047176616&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/47312-
dc.description.abstract© 2018 by the authors. One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-L-tryptophan. Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 potently induced apoptosis of gastric cancer cells by inhibiting topoisomerase IIα enzyme activity and reducing the expression of antiapoptosis protein level. Compound 3 displayed moderate cytotoxicity against the A549 and MCF-7 cell lines with IC50 values of 1.2 ± 0.05 µM, 1.6 ± 0.09 µM, respectively.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047176616&origin=inwarden_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titlePrecursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activityen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.3390/md16050168en_US
Appears in Collections:Scopus 2018

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