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dc.contributor.authorKayla Ann Andrewsen_US
dc.contributor.authorDavid Wescheen_US
dc.contributor.authorJames McCarthyen_US
dc.contributor.authorJörg J. Möhrleen_US
dc.contributor.authorJoel Tarningen_US
dc.contributor.authorLuann Phillipsen_US
dc.contributor.authorSteven Kernen_US
dc.contributor.authorThaddeus Graselaen_US
dc.contributor.otherUniversity at Buffalo, State University of New Yorken_US
dc.contributor.otherUniversity of Queenslanden_US
dc.contributor.otherQIMR Berghofer Medical Research Instituteen_US
dc.contributor.otherBill and Melinda Gates Foundationen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherCognigen Corporationen_US
dc.contributor.otherMedicines for Malaria Ventureen_US
dc.identifier.citationAnnual Review of Pharmacology and Toxicology. Vol.58, (2018), 567-582en_US
dc.description.abstract© 2018 Kayla Ann Andrews et al. Malaria is a critical public health problem resulting in substantial morbidity and mortality, particularly in developing countries. Owing to the development of resistance toward current therapies, novel approaches to accelerate the development efforts of new malaria therapeutics are urgently needed. There have been significant advancements in the development of in vitro and in vivo experiments that generate data used to inform decisions about the potential merit of new compounds. A comprehensive disease-drug model capable of integrating discrete data from different preclinical and clinical components would be a valuable tool across all stages of drug development. This could have an enormous impact on the otherwise slow and resource-intensive process of traditional clinical drug development.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleModel-Informed Drug Development for Malaria Therapeuticsen_US
Appears in Collections:Scopus 2018

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