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dc.contributor.authorTeerayut Sriyatepen_US
dc.contributor.authorCholpisut Tantapakulen_US
dc.contributor.authorRaymond J. Andersenen_US
dc.contributor.authorBrian O. Patricken_US
dc.contributor.authorStephen G. Pyneen_US
dc.contributor.authorChatchai Muanprasaten_US
dc.contributor.authorSawinee Seemakhanen_US
dc.contributor.authorSuparerk Borwornpinyoen_US
dc.contributor.authorSurat Laphookhieoen_US
dc.contributor.otherMae Fah Luang Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Wollongongen_US
dc.contributor.otherThe University of British Columbiaen_US
dc.identifier.citationFitoterapia. Vol.124, (2018), 34-41en_US
dc.description.abstract© 2017 A new scalemic 8,8a-dihydro caged xanthone (1) was isolated from the leaf extract of Garcinia propinqua. Five other known natural products, the three caged xanthones (2, 5 and 6) and the two neocaged xanthones, (3 and 4) were also isolated as scalemic mixtures. Their structures were characterized by spectroscopic methods. The enantiomeric ratios (er) of compounds 1–6 ranged from 1:0.7 to 1:0.9. These compounds were also resolved by semipreparative chiral HPLC. The absolute configurations of (+)-2 and (+)-3 were determined by single-crystal X-ray diffraction analysis using Cu Kα radiation while the absolute configurations of the other compounds were determined by comparisons of their ECD spectra. Compounds (−)-4, (+)-4, (−)-5, (+)-5, and (−)-6 showed potent cytotoxicities against a colon cancer cell line HCT116 with IC50 values of 2.60, 7.02, 1.47, 3.37, and 4.14 μM, respectively, which were better than the standard control doxorubicin (IC50 9.74 μM).en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleResolution and identification of scalemic caged xanthones from the leaf extract of Garcinia propinqua having potent cytotoxicities against colon cancer cellsen_US
Appears in Collections:Scopus 2018

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