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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/47462
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dc.contributor.authorKanjana Srisutthisamphanen_US
dc.contributor.authorKrit Jirakanwisalen_US
dc.contributor.authorSuwipa Ramphanen_US
dc.contributor.authorNatthida Tongluanen_US
dc.contributor.authorAtichat Kuadkitkanen_US
dc.contributor.authorDuncan R. Smithen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2019-08-28T07:10:53Z-
dc.date.available2019-08-28T07:10:53Z-
dc.date.issued2018-12-01en_US
dc.identifier.citationScientific Reports. Vol.8, No.1 (2018)en_US
dc.identifier.issn20452322en_US
dc.identifier.other2-s2.0-85043989613en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85043989613&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/47462-
dc.description.abstract© 2018 The Author(s). Infections with the mosquito-borne dengue virus (DENV) remain a significant public health challenge. In the absence of a commercial therapeutic to treat DENV infection, a greater understanding of the processes of cellular replication is required. The abundant cellular chaperone protein heat shock protein 90 (Hsp90) has been shown to play a proviral role in the replication cycle of several viruses, predominantly through the stabilization of specific viral proteins. To investigate any potential role of Hsp90 in DENV infection the interaction between Hsp90 and DENV proteins was determined through co-immunoprecipitation experiments. Six DENV proteins namely envelope (E) and nonstructural (NS) proteins NS1, NS2B, NS3, NS4B and NS5 were shown to interact with Hsp90, and four of these proteins (E, NS1, NS3 and NS5) were shown to colocalize to a variable extent with Hsp90. Despite the extensive interactions between Hsp90 and DENV proteins, inhibition of the activity of Hsp90 had a relatively minor effect on DENV replication, with inhibition of Hsp90 resulting in a decrease of cellular E protein (but not nonstructural proteins) coupled with an increase of E protein in the medium and an increased virus titer. Collectively these results indicate that Hsp90 has a slight anti-viral effect in DENV infection.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85043989613&origin=inwarden_US
dc.subjectMultidisciplinaryen_US
dc.titleHsp90 interacts with multiple dengue virus 2 proteinsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1038/s41598-018-22639-5en_US
Appears in Collections:Scopus 2018

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