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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/47489
Title: More evening preference is positively associated with systemic inflammation in prediabetes and type 2 diabetes patients
Authors: Hataikarn Nimitphong
Apichana Mahattanapreut
La or Chailurkit
Sunee Saetung
Nantaporn Siwasaranond
Rungtip Sumritsopak
Thunyarat Anothaisintawee
Ammarin Thakkinstian
Lara R. Dugas
Brian T. Layden
Sirimon Reutrakul
Loyola University Stritch School of Medicine
University of Illinois at Chicago
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
Jesse Brown Veterans Affairs Medical Center
Keywords: Multidisciplinary
Issue Date: 1-Dec-2018
Citation: Scientific Reports. Vol.8, No.1 (2018)
Abstract: © 2018, The Author(s). Currently it is not known whether morningness-eveningness preference in non-night shift working population is associated with systemic inflammation. This study investigated the relationship between morningness-eveningness and systemic inflammation, as measured by high-sensitivity C-reactive protein (hs-CRP) in 163 non-night shift working patients with abnormal glucose tolerance (86 type 2 diabetes and 77 prediabetes). Morningness-eveningness was assessed by Composite Scale of Morningness, and participants were screened for Obstructive sleep apnea (OSA). Sleep duration, efficiency, and variability were obtained using actigraphy, and depressive symptoms and dietary patterns were also captured. Participants’ mean age was 54.7 ± 10.4 years and median hs-CRP was 1.39 (interquartile range 0.82, 3.33) mg/L. More evening preference was significantly associated with higher natural log transformed (ln) hs-CRP (B = −0.051, p = 0.001). Diabetes status, glycemic control, OSA severity, sleep duration, caloric consumption and timing were not related to hs-CRP. After adjusting for age, sex, body mass index, depressive symptoms, sleep efficiency, sleep variability, percentage of daily caloric intake from protein, and statin use, more evening preference was independently associated with higher ln hs-CRP (B = −0.032, p = 0.014). In summary, in non-night shift working patients with abnormal glucose tolerance, more evening preference was independently associated with higher systemic inflammation. This finding underscore the importance of circadian regulation on cardiovascular health.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055617504&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/47489
ISSN: 20452322
Appears in Collections:Scopus 2018

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