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dc.contributor.authorDuangkamon Bunditvorapoomen_US
dc.contributor.authorTheerarat Kochakarnen_US
dc.contributor.authorNamfon Kotananen_US
dc.contributor.authorCharin Modchangen_US
dc.contributor.authorKrittikorn Kümpornsinen_US
dc.contributor.authorDuangkamon Loesbanluechaien_US
dc.contributor.authorThanyaluk Krasaeen_US
dc.contributor.authorLiwang Cuien_US
dc.contributor.authorKesinee Chotivanichen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorPrapon Wilairaten_US
dc.contributor.authorOlivo Miottoen_US
dc.contributor.authorThanat Chookajornen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherWellcome Sanger Instituteen_US
dc.contributor.otherPennsylvania State Universityen_US
dc.identifier.citationScientific Reports. Vol.8, No.1 (2018)en_US
dc.description.abstract© 2018, The Author(s). Artemisinin is the most rapidly effective drug for Plasmodium falciparum malaria treatment currently in clinical use. Emerging artemisinin-resistant parasites pose a great global health risk. At present, the level of artemisinin resistance is still relatively low with evidence pointing towards a trade-off between artemisinin resistance and fitness loss. Here we show that artemisinin-resistant P. falciparum isolates from Cambodia manifested fitness loss, showing fewer progenies during the intra-erythrocytic developmental cycle. The loss in fitness was exacerbated under the condition of low exogenous amino acid supply. The resistant parasites failed to undergo maturation, whereas their drug-sensitive counterparts were able to complete the erythrocytic cycle under conditions of amino acid deprivation. The artemisinin-resistant phenotype was not stable, and loss of the phenotype was associated with changes in the expression of a putative target, Exp1, a membrane glutathione transferase. Analysis of SNPs in haemoglobin processing genes revealed associations with parasite clearance times, suggesting changes in haemoglobin catabolism may contribute to artemisinin resistance. These findings on fitness and protein homeostasis could provide clues on how to contain emerging artemisinin-resistant parasites.en_US
dc.rightsMahidol Universityen_US
dc.titleFitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodiaen_US
Appears in Collections:Scopus 2018

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