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dc.contributor.authorThidarat Rujirawaten_US
dc.contributor.authorPreecha Patumcharoenpolen_US
dc.contributor.authorTassanee Lohnooen_US
dc.contributor.authorWanta Yingyongen_US
dc.contributor.authorYothin Kumsangen_US
dc.contributor.authorPenpan Payattikulen_US
dc.contributor.authorSithichoke Tangphatsornruangen_US
dc.contributor.authorPrapat Suriyapholen_US
dc.contributor.authorOnrapak Reamtongen_US
dc.contributor.authorGagan Gargen_US
dc.contributor.authorWeerayuth Kittichotiraten_US
dc.contributor.authorTheerapong Krajaejunen_US
dc.contributor.otherUniversity of Arkansas for Medical Sciencesen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherKing Mongkut s University of Technology Thonburien_US
dc.contributor.otherCSIRO Agriculture and Fooden_US
dc.identifier.citationScientific Reports. Vol.8, No.1 (2018)en_US
dc.description.abstract© 2018 The Author(s). Pythium insidiosum is a human-pathogenic oomycete. Many patients infected with it lose organs or die. Toward the goal of developing improved treatment options, we want to understand how Py. insidiosum has evolved to become a successful human pathogen. Our approach here involved the use of comparative genomic and other analyses to identify genes with possible functions in the pathogenicity of Py. insidiosum. We generated an Oomycete Gene Table and used it to explore the genome contents and phylogenomic relationships of Py. insidiosum and 19 other oomycetes. Initial sequence analyses showed that Py. insidiosum is closely related to Pythium species that are not pathogenic to humans. Our analyses also indicated that the organism harbours secreted and adhesin-like proteins, which are absent from related species. Putative virulence proteins were identified by comparison to a set of known virulence genes. Among them is the urease Ure1, which is absent from humans and thus a potential diagnostic and therapeutic target. We used mass spectrometric data to successfully validate the expression of 30% of 14,962 predicted proteins and identify 15 body temperature (37°C)-dependent proteins of Py. insidiosum. This work begins to unravel the determinants of pathogenicity of Py. insidiosum.en_US
dc.rightsMahidol Universityen_US
dc.titleProbing the Phylogenomics and Putative Pathogenicity Genes of Pythium insidiosum by Oomycete Genome Analysesen_US
Appears in Collections:Scopus 2018

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