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Title: Evidence for Host-Bacterial Co-evolution via Genome Sequence Analysis of 480 Thai Mycobacterium tuberculosis Lineage 1 Isolates
Authors: Prasit Palittapongarnpim
Pravech Ajawatanawong
Wasna Viratyosin
Nat Smittipat
Areeya Disratthakit
Surakameth Mahasirimongkol
Hideki Yanai
Norio Yamada
Supalert Nedsuwan
Worarat Imasanguan
Pacharee Kantipong
Boonchai Chaiyasirinroje
Jiraporn Wongyai
Licht Toyo-oka
Jody Phelan
Julian Parkhill
Taane G. Clark
Martin L. Hibberd
Wuthiwat Ruengchai
Panawun Palittapongarnpim
Tada Juthayothin
Sissades Tongsima
Katsushi Tokunaga
Japan Anti-Tuberculosis Association
London School of Hygiene & Tropical Medicine
University of Tokyo
Thailand Ministry of Public Health
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
Wellcome Sanger Institute
TB/HIV Research Foundation
Keywords: Multidisciplinary
Issue Date: 1-Dec-2018
Citation: Scientific Reports. Vol.8, No.1 (2018)
Abstract: © 2018, The Author(s). Tuberculosis presents a global health challenge. Mycobacterium tuberculosis is divided into several lineages, each with a different geographical distribution. M. tuberculosis lineage 1 (L1) is common in the high-burden areas in East Africa and Southeast Asia. Although the founder effect contributes significantly to the phylogeographic profile, co-evolution between the host and M. tuberculosis may also play a role. Here, we reported the genomic analysis of 480 L1 isolates from patients in northern Thailand. The studied bacterial population was genetically diverse, allowing the identification of a total of 18 sublineages distributed into three major clades. The majority of isolates belonged to L1.1 followed by L1.2.1 and L1.2.2. Comparison of the single nucleotide variant (SNV) phylogenetic tree and the clades defined by spoligotyping revealed some monophyletic clades representing EAI2_MNL, EAI2_NTM and EAI6_BGD1 spoligotypes. Our work demonstrates that ambiguity in spoligotype assignment could be partially resolved if the entire DR region is investigated. Using the information to map L1 diversity across Southeast Asia highlighted differences in the dominant strain-types in each individual country, despite extensive interactions between populations over time. This finding supported the hypothesis that there is co-evolution between the bacteria and the host, and have implications for tuberculosis disease control.
ISSN: 20452322
Appears in Collections:Scopus 2018

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