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Title: A study on ACE, ACTN3, and VDR genes polymorphism in Thai weightlifters
Authors: Luckhana Pimjan
Chalermporn Ongvarrasopone
Wasun Chantratita
Chumpol Polpramool
Pipat Cherdrungsi
Phuwadol Bangrak
Tossaporn Yimlamai
Walailak University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
Institute of Molecular Biosciences
Keywords: Multidisciplinary
Issue Date: 1-Sep-2018
Citation: Walailak Journal of Science and Technology. Vol.15, No.9 (2018), 609-626
Abstract: © 2018, Walailak University. All rights reserved. In order to excel in sport, apart from the correct training, the genetic combination of an individual may also be a factor in making an elite athlete. Weightlifting, as a popular sport, has a unique bio-mechanism dealing with muscle performance. The current study investigated the polymorphisms of the angiotensin-converting enzyme (ACE), the α-actinin-3 (ACTN3), and the vitamin D receptor (VDR) genes (individually or in combination) in Thai weightlifters. A total of 117 male and female national and junior Thai weightlifters, and 99 healthy sedentary people were recruited for this study. Genotyping was analyzed by Polymerase Chain Reaction (PCR) and Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). When compared to the junior and non-athletes group, the genotype and allele frequencies of ACE (DD), ACTN3 (RR), and VDR (ff) were more frequent in both male and female national weightlifters. In addition, the genotype combinations between ACE (DD) + VDR (ff), ACE (DD) + ACTN3 RR, and ACTN3 RR + VDR ff presented highly in both genders of national weightlifters. Taken together, our results suggest that the ACTN3 and VDR genotype, individually or in combination, may influence muscle performance in weightlifters, appearing to significantly contribute to better weightlifting performance.
ISSN: 2228835X
Appears in Collections:Scopus 2018

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