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Title: Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
Authors: Jakub Gruszczyk
Usheer Kanjee
Li Jin Chan
Sébastien Menant
Benoit Malleret
Nicholas T.Y. Lim
Christoph Q. Schmidt
Yee Foong Mok
Kai Min Lin
Richard D. Pearson
Gabriel Rangel
Brian J. Smith
Melissa J. Call
Michael P. Weekes
Michael D.W. Griffin
James M. Murphy
Jonathan Abraham
Kanlaya Sriprawat
Maria J. Menezes
Marcelo U. Ferreira
Bruce Russell
Laurent Renia
Manoj T. Duraisingh
Wai Hong Tham
A-Star, Singapore Immunology Network
Cambridge Institute for Medical Research
Harvard School of Public Health
Walter and Eliza Hall Institute of Medical Research
Yong Loo Lin School of Medicine
University of Melbourne
University of Otago
Mahidol University
Universität Ulm
Universidade de Sao Paulo - USP
La Trobe University
Wellcome Sanger Institute
Harvard Medical School
Li Ka Shing Centre for Health Information and Discovery
Keywords: Multidisciplinary
Issue Date: 5-Jan-2018
Citation: Science. Vol.359, No.6371 (2018), 48-55
Abstract: Plasmodium vivax shows a strict host tropism for reticulocytes.We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b).We determined the structure of the N-terminal domain of PvRBP2b involved in red blood cell binding, elucidating the molecular basis for TfR1 recognition.We validated TfR1 as the biological target of PvRBP2b engagement by means of TfR1 expression knockdown analysis. TfR1 mutant cells deficient in PvRBP2b binding were refractory to invasion of P. vivax but not to invasion of P. falciparum. Using Brazilian and Thai clinical isolates, we show that PvRBP2b monoclonal antibodies that inhibit reticulocyte binding also block P. vivax entry into reticulocytes.These data show that TfR1-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion.
ISSN: 10959203
Appears in Collections:Scopus 2018

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