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Title: Pyranonaphthoquinone and anthraquinone derivatives from Ventilago harmandiana and their potent anti-inflammatory activity
Authors: Kanda Panthong
Sakchai Hongthong
Chutima Kuhakarn
Pawinee Piyachaturawat
Kanoknetr Suksen
Ampai Panthong
Natthakarn Chiranthanut
Palangpon Kongsaeree
Samran Prabpai
Narong Nuntasaen
Vichai Reutrakul
Mahidol University
Chiang Mai University
Rajabhat Rajanagarindra University
Ministry of Natural Resources and Environment
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2020
Citation: Phytochemistry. Vol.169, (2020)
Abstract: © 2019 Elsevier Ltd The chemical study on the heartwoods extract of Ventilago harmandiana (Rhamnaceae) resulted in the isolation of ten previously undescribed pyranonaphthoquinones (ventilanones A−J), an undescribed anthraquinone (ventilanone K), together with eight known anthraquinone derivatives. Their structures were elucidated by extensive analysis of their spectroscopic data. The absolute configuration of ventilanone A was established from single crystal X-ray crystallographic analysis of its p-bromobenzenesulfonate ester derivative using Cu Kα radiation. The absolute configurations of the other related compounds were identified by comparison of their ECD data with those of ventilanone A and related known compounds. Cytotoxic and anti-inflammatory activities of some of the isolated compounds were evaluated. Ventilanone A and ventilanone C exhibited moderate cytotoxicity against P-388 cell line. Ventilanone D exhibited significant anti-inflammatory activity while ventilanone A and ventilanone C showed moderate activity.
ISSN: 00319422
Appears in Collections:Scopus 2020

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