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|Title:||Derivation of human embryonic stem cell line MUSIe001-A from an embryo with homozygous α<sup>0</sup>-thalassemia (SEA deletion)|
Faculty of Medicine, Thammasat University
Faculty of Medicine, Siriraj Hospital, Mahidol University
|Keywords:||Biochemistry, Genetics and Molecular Biology|
|Citation:||Stem Cell Research. Vol.43, (2020)|
|Abstract:||© 2020 The Authors MUSIe001-A cell line was derived from a Southeast Asian (SEA) type deletion α0-thalassemia embryo. The SEA deletion embryo was donated for research with informed consent. This cell line shows normal hESC morphology, expresses all pluripotent markers, and has the potential to differentiate into all three germ layers in vitro and in vivo. The MUSIe001-A line has normal karyotype and is free from mycoplasma contamination. PCR analysis confirmed the MUSIe001-A cell line to be a SEA type deletion. MUSIe001-A is a valuable proof of principle model for gene therapy that will facilitate the development of new treatments for affected foetuses.|
|Appears in Collections:||Scopus 2020|
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