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Title: Association of carbamazepine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis with the HLA-B75 serotype or HLA-B*15:21 allele in Filipino patients
Authors: Francis Capule
Pramote Tragulpiankit
Surakameth Mahasirimongkol
Jiraphun Jittikoon
Nuanjun Wichukchinda
Lara Theresa Alentajan-Aleta
Jay V. James Barit
Josephine Casanova-Gutierrez
Leonor Cabral-Lim
Jose Paciano Baltazar Reyes
Francisca Roa
Raymark Salonga
Katrina Faith San Gabriel
Catherine Lynn Silao
University of the Philippines Manila
University of the East Ramon Magsaysay Memorial Medical Center
Thailand Ministry of Public Health
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2020
Citation: Pharmacogenomics Journal. (2020)
Abstract: © 2020, The Author(s), under exclusive licence to Springer Nature Limited. A case-control study was conducted to investigate the association of HLA-A alleles, HLA-B alleles including HLA-B*15:02 and HLA-B75 serotype with carbamazepine-induced SJS/TEN in Filipino patients. A retrospective review of medical records was performed. Pertinent clinical data were collected. Eight (8) carbamazepine-induced SJS/TEN cases and 32 tolerant controls were recruited. Genomic DNA was extracted from the saliva samples and genotyping was performed by employing allele-specific polymerase chain reaction. Data were analyzed using the Fisher's exact test, Mann–Whitney U test, univariate logistic regression, and multivariate logistic regression. Single allele association analysis was done. The strength of association was expressed as odds ratio with 95% confidence interval. Positive predictive value, negative predictive value, sensitivity, and specificity were computed. Of all the alleles tested, the HLA-B75 serotype (p = 0.007, OR = 23.25, 95% CI = 2.33–232.21) and HLA-B*15:21 (p = 0.026, OR = 7.53, 95% CI = 1.27–44.79) were significantly associated with carbamazepine-induced SJS/TEN. The HLA-B75 serotype or HLA-B*15:21 allele may be used as a genetic risk assessment prior to prescription for prevention of carbamazepine-induced SJS/TEN in Filipino patients.
ISSN: 14731150
Appears in Collections:Scopus 2020

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