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Title: Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group
Authors: Kitsada Wudhikarn
Udomsak Bunworasate
Jakrawadee Julamanee
Arnuparp Lekhakula
Supachai Ekwattanakit
Archrob Khuhapinant
Suporn Chuncharunee
Pimjai Niparuck
Tontanai Numbenjapon
Kannadit Prayongratana
Nonglak Kanitsap
Somchai Wongkhantee
Nisa Makruasi
Peerapon Wong
Lalita Norasetthada
Weerasak Nawarawong
Chittima Sirijerachai
Kanchana Chansung
Tawatchai Suwanban
Pannee Praditsuktavorn
Tanin Intragumtornchai
Chulalongkorn University
Naresuan University
Khon Kaen University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Thammasat University
Faculty of Medicine, Siriraj Hospital, Mahidol University
Phramongkutklao College of Medicine
Prince of Songkla University
Rajavithi Hospital
Chiang Mai University
Srinakharinwirot University
Khonkaen Regional Hospital
Chulabhorn Hospital
Keywords: Medicine
Issue Date: 1-Jan-2020
Citation: Journal of Geriatric Oncology. Vol.11, No.1 (2020), 62-68
Abstract: © 2019 Introduction: Peripheral T cell NHL (PTCL) and natural killer/T cell NHL (NKTCL) are relatively rare disorders. Data on clinical presentation, treatment and outcome are limited especially in older age groups. Methods: We identified 127 patients with PTCL and NKTCL, excluding cutaneous T/NK cell lymphoma, aged over 60 years old from Thailand nationwide multicenter registry. Results: Of 127 patients, median age of diagnosis was 67 years old. Patients aged older than 75 years old had similar characteristics to younger (60–74 years old) but higher comorbidity index. Seventy-nine patients (62.2%) received intensive/definite multi-agent chemotherapy, however, the proportion was significant lower in older patients (70.4% vs 34.5%, p <. 001). After a median follow up duration of 17.3 months, 2-year progression free survival and overall survival were 38.1% and 48.5%. Univariate and multivariable analysis demonstrated older age, poor performance status and absence of definite multi-agent chemotherapy were associated with inferior survival. Definite multi-agent lymphoma specific chemotherapy was an independent factor for overall survival after adjustment for age, comorbidity index, performance status and prognostic index for T cell lymphoma. Conclusion: Despite overall poor prognosis of PTCL and NKTCL in older adults, chemotherapy could result in objective response and long-term survival in selected patients of this vulnerable age group thus emphasizing the importance of comprehensive geriatric evaluation.
ISSN: 18794068
Appears in Collections:Scopus 2020

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