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Title: Prognostic factors for TB-associated uveitis in the Asia-Pacific Region: results of a modified Delphi survey
Authors: Soumyava Basu
Rina La Distia Nora
Narsing A. Rao
Xuejuan Jiang
Ahmad Fuady
Peter J. McCluskey
Justine R. Smith
Soumyava Basu
Jyotirmay Biswas
Padmamalini Mahendradas
Salil Mehta
Kalpana Babu Murthy
Lukman Edwar
Kazuichi Murayama
Shelina Oli Mohamed
May Z.A. Win
Jessica Marie Abaño
Soon Phaik Chee
Shwu Jiuan Sheu
Somsiri Sukavatcharin
Narsing A. Rao
De La Salle Health Sciences Institute
Lilavati Hospital & Research Centre, Mumbai
Kaohsiung Medical University Chung-Ho Memorial Hospital
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Universitas Indonesia
Yong Loo Lin School of Medicine
Sankara Nethralaya
Osaka University
Flinders University
L.V. Prasad Eye Institute India
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keck School of Medicine of USC
Save Sight Institute
Uveitis and Ocular Immunology Department
Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Centre
University of Medicine 1
Hospital Shah Alam
Keywords: Medicine;Neuroscience
Issue Date: 1-Jan-2020
Citation: Eye (Basingstoke). (2020)
Abstract: © 2020, The Author(s), under exclusive licence to The Royal College of Ophthalmologists. Background: Prognostic factors for TB-associated uveitis (TBU) remain mostly unknown, due to the challenges in interpretation of patient data. We present consensus list of prognostic factors for resolution of inflammation in TBU, by experts across the Asia-Pacific region. Methods: We applied a modified Delphi technique to generate consensus on prognostic factors influencing the resolution of inflammation in TB-associated: anterior uveitis (AU), retinal vasculitis (RV), and multifocal serpiginoid choroiditis (MSC). The initial questionnaire was developed through a face-to-face meeting. Sixteen uveitis experts from eleven Asia-Pacific countries were included. A single investigator circulated the questionnaire electronically and received the responses. Participants scored each item on 4-point Likert scale, in three successive rounds. After each round, a number of items were reduced based on response, and summary of responses was provided to participants. At the end of Round 3, items were considered significant if they: (1) achieved a median ≥2, and interquartile range ≤1, and (2) ≥75% of the respondents agreed on whether the item was a positive or negative prognostic factor. Results: Forty-two putative questionnaire items were considered. At the end of Rounds 3, 4, 9, and 8 items in AU, RV, and MSC, respectively, met significance criteria. These included duration of disease, previous corticosteroid/immunosuppressive therapy, co-existent HIV, disease-specific imaging features, multidrug resistant TB, and duration of anti-TB therapy. Conclusions: Consensus were achieved on multiple ocular and systemic factors that influence resolution of inflammation in TBU. These will form the groundwork for validation in prospective clinical trials.
ISSN: 14765454
Appears in Collections:Scopus 2020

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