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dc.contributor.authorHirofumi Akiyamaen_US
dc.contributor.authorNaoya Okuen_US
dc.contributor.authorEnjuro Harunarien_US
dc.contributor.authorWatanalai Panbangreden_US
dc.contributor.authorYasuhiro Igarashien_US
dc.contributor.otherToyama Prefectural Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationJournal of Antibiotics. Vol.73, No.1 (2020), 60-65en_US
dc.description.abstract© 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. A norditerpenoid k4610422 (1), an inhibitor of testosterone-5α-reductase originally discovered from a mesophilic rare actinomycete of the genus Streptosporangium, was isolated from the culture extract of a thermophilic actinomycete Actinomadura sp. The complete 1H and 13C NMR assignment and absolute configuration of 1 were addressed by spectroscopic measurements including NOESY and CD spectra coupled with ECD calculation, which allowed to establish the (5 R,9 S,10 R,13 S)-configuration. Compound 1 was moderately cytotoxic against P388 murine leukemia cells with IC50 30 μM.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleComplete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomaduraen_US
Appears in Collections:Scopus 2020

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