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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/49805
Title: Hematopoietic tissue of Macrobrachium rosenbergii plays dual roles as a source of hemocyte hematopoiesis and as a defensive mechanism against Macrobrachium rosenbergii nodavirus infection
Authors: Pitchanee Jariyapong
Arnon Pudgerd
Nifareesa Cheloh
Ikuo Hirono
Hidehiro Kondo
Rapeepun Vanichviriyakit
Wattana Weerachatyanukul
Charoonroj Chotwiwatthanakun
University of Phayao
Walailak University
National University Corporation Tokyo University of Marine Science and Technology
Mahidol University
Princess of Naradhiwas University
Keywords: Agricultural and Biological Sciences;Environmental Science
Issue Date: 1-Mar-2019
Citation: Fish and Shellfish Immunology. Vol.86, (2019), 756-763
Abstract: © 2018 Elsevier Ltd White tail disease caused by Macrobrachium rosenbergii nodavirus (MrNV) infection takes place only in nauplii, not adults, of M. rosenbergii prawn. Hemocyte homeostasis and immune-related functions derived from the hematopoietic tissue (Hpt) in adult prawn are presumed to play roles in resisting viral infection. To elucidate the role of the Hpt cell response to MrNV, a comparative transcriptome analysis was performed with MrNV-infected prawn at various time intervals. The results showed that there were 462 unigenes that were differentially expressed between mock and infected samples. BlastX sequence analysis revealed that two proteins, crustacean hematopoietic factor (CHF) and cell growth-regulating zinc finger protein (Lyar), are involved in hemocyte hematopoiesis and are up-regulated during MrNV infection. In fact, genes involved in cell growth regulation and immunity were highly expressed at 6 h and decreased within 24 h post-infection. Localization studies in the Hpt tissue revealed the presence of anti-lipopolysaccharide factor (ALF) and CHF mRNAs in Hpt cells. Considering these findings, we concluded that resistance to MrNV infection in adult prawn is due to an increase in humoral immune factors and the acceleration of hemocyte homeostasis by the dual roles of the Hpt organ in M. rosenbergii.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/49805
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058440208&origin=inward
ISSN: 10959947
10504648
Appears in Collections:Scopus 2019

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