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dc.contributor.authorMuhamad Rusdi Ahmad Rusmilien_US
dc.contributor.authorIekhsan Othmanen_US
dc.contributor.authorSyafiq Asnawi Zainal Abidinen_US
dc.contributor.authorFathin Athirah Yusofen_US
dc.contributor.authorKavi Ratanabanangkoonen_US
dc.contributor.authorLawan Chanhomeen_US
dc.contributor.authorWayne C. Hodgsonen_US
dc.contributor.authorJaneyuth Chaisakulen_US
dc.contributor.otherMonash Universityen_US
dc.contributor.otherMonash University Malaysiaen_US
dc.contributor.otherInternational Islamic University Malaysiaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPhramongkutklao College of Medicineen_US
dc.contributor.otherQueen Saovabha Memorial Instituteen_US
dc.date.accessioned2020-01-27T07:31:27Z-
dc.date.available2020-01-27T07:31:27Z-
dc.date.issued2019-01-01en_US
dc.identifier.citationPLoS ONE. Vol.14, No.12 (2019)en_US
dc.identifier.issn19326203en_US
dc.identifier.other2-s2.0-85077307546en_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/49928-
dc.description.abstract© 2019 Rusmili et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Malayan krait (Bungarus candidus) is a medically important snake species found in Southeast Asia. The neurotoxic effects of envenoming present as flaccid paralysis of skeletal muscles. It is unclear whether geographical variation in venom composition plays a significant role in the degree of clinical neurotoxicity. In this study, the effects of geographical variation on neurotoxicity and venom composition of B. candidus venoms from Indonesia, Malaysia and Thailand were examined. In the chick biventer cervicis nerve-muscle preparation, all venoms abolished indirect twitches and attenuated contractile responses to nicotinic receptor agonists, with venom from Indonesia displaying the most rapid neurotoxicity. A proteomic analysis indicated that three finger toxins (3FTx), phospholipase A2 (PLA2) and Kunitz-type serine protease inhibitors were common toxin groups in the venoms. In addition, venom from Thailand contained L-amino acid oxidase (LAAO), cysteine rich secretory protein (CRISP), thrombin-like enzyme (TLE) and snake venom metalloproteinase (SVMP). Short-chain post-synaptic neurotoxins were not detected in any of the venoms. The largest quantity of long-chain post-synaptic neurotoxins and non-conventional toxins was found in the venom from Thailand. Analysis of PLA2 activity did not show any correlation between the amount of PLA2 and the degree of neurotoxicity of the venoms. Our study shows that variation in venom composition is not limited to the degree of neurotoxicity. This investigation provides additional insights into the geographical differences in venom composition and provides information that could be used to improve the management of Malayan krait envenoming in Southeast Asia.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077307546&origin=inwarden_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleVariations in neurotoxicity and proteome profile of Malayan krait (Bungarus candidus) venomsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1371/journal.pone.0227122en_US
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077307546&origin=inwarden_US
Appears in Collections:Scopus 2019

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