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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/50019
Title: Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children
Authors: Palang Chotsiri
Issaka Zongo
Paul Milligan
Yves Daniel Compaore
Anyirékun Fabrice Somé
Daniel Chandramohan
Warunee Hanpithakpong
François Nosten
Brian Greenwood
Philip J. Rosenthal
Nicholas J. White
Jean Bosco Ouédraogo
Joel Tarning
London School of Hygiene & Tropical Medicine
University of California, San Francisco
Mahidol University
Nuffield Department of Clinical Medicine
Institut de Recherche en Sciences de la Santé
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 1-Dec-2019
Citation: Nature Communications. Vol.10, No.1 (2019)
Abstract: © 2019, The Author(s). Young children are the population most severely affected by Plasmodium falciparum malaria. Seasonal malaria chemoprevention (SMC) with amodiaquine and sulfadoxine-pyrimethamine provides substantial benefit to this vulnerable population, but resistance to the drugs will develop. Here, we evaluate the use of dihydroartemisinin-piperaquine as an alternative regimen in 179 children (aged 2.33–58.1 months). Allometrically scaled body weight on pharmacokinetic parameters of piperaquine result in lower drug exposures in small children after a standard mg per kg dosage. A covariate-free sigmoidal E MAX -model describes the interval to malaria re-infections satisfactorily. Population-based simulations suggest that small children would benefit from a higher dosage according to the WHO 2015 guideline. Increasing the dihydroartemisinin-piperaquine dosage and extending the dose schedule to four monthly doses result in a predicted relative reduction in malaria incidence of up to 58% during the high transmission season. The higher and extended dosing schedule to cover the high transmission period for SMC could improve the preventive efficacy substantially.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/50019
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060817483&origin=inward
ISSN: 20411723
Appears in Collections:Scopus 2019

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