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Title: Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages
Authors: Adeline C.Y. Chua
Jessica Jie Ying Ong
Benoit Malleret
Rossarin Suwanarusk
Varakorn Kosaisavee
Anne Marie Zeeman
Caitlin A. Cooper
Kevin S.W. Tan
Rou Zhang
Bee Huat Tan
Siti Nurdiana Abas
Andy Yip
Anne Elliot
Chester J. Joyner
Jee Sun Cho
Kate Breyer
Szczepan Baran
Amber Lange
Steven P. Maher
François Nosten
Christophe Bodenreider
Bryan K.S. Yeung
Dominique Mazier
Mary R. Galinski
Nathalie Dereuddre-Bosquet
Roger Le Grand
Clemens H.M. Kocken
Laurent Rénia
Dennis E. Kyle
Thierry T. Diagana
Georges Snounou
Bruce Russell
Pablo Bifani
A-Star, Singapore Immunology Network
Centre de Recherche en Immunologie des Infections Virales et des Maladies Auto-Immunes
London School of Hygiene & Tropical Medicine
The University of Georgia
Yong Loo Lin School of Medicine
Novartis Institute for Tropical Diseases Pte. Ltd.
Biomedical Primate Research Centre - Rijswijk
University of Otago
Mahidol University
Nuffield Department of Clinical Medicine
Sorbonne Universite
Emory University
Novartis Institutes for BioMedical Research
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 1-Dec-2019
Citation: Nature Communications. Vol.10, No.1 (2019)
Abstract: © 2019, The Author(s). The ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and the development of vaccines and drugs. Thus, the elaboration of a protocol for the in vitro cultivation of the erythrocytic stages of Plasmodium falciparum revolutionized research on this important parasite. However, for P. vivax, the most widely distributed and difficult to treat malaria parasite, a strict preference for reticulocytes thwarts efforts to maintain it in vitro. Cultivation of P. cynomolgi, a macaque-infecting species phylogenetically close to P. vivax, was briefly reported in the early 1980s, but not pursued further. Here, we define the conditions under which P. cynomolgi can be adapted to long term in vitro culture to yield parasites that share many of the morphological and phenotypic features of P. vivax. We further validate the potential of this culture system for high-throughput screening to prime and accelerate anti-P. vivax drug discovery efforts.
ISSN: 20411723
Appears in Collections:Scopus 2019

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