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Title: Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns
Authors: Amol C. Shetty
Christopher G. Jacob
Fang Huang
Yao Li
Sonia Agrawal
David L. Saunders
Chanthap Lon
Mark M. Fukuda
Pascal Ringwald
Elizabeth A. Ashley
Kay Thwe Han
Tin Maung Hlaing
Myaing M. Nyunt
Joana C. Silva
Kathleen E. Stewart
Christopher V. Plowe
Timothy D. O’Connor
Shannon Takala-Harrison
Harald Noedl
Wasif A. Khan
Paul Newton
Myat P. Kyaw
Nicholas J. White
Arjen M. Dondorp
Nicholas P. Day
Charles J. Woodrow
Mehul Dhorda
M. Abul Faiz
Rick M. Fairhurst
Pharath Lim
Rupam Tripura
Mayfong Mayxay
Ye Htut
Francois Nosten
Aung Pyae Phyo
Sasithon Pukrittayakamee
Tran Tinh Hien
Nguyen Thanh Thuy Nhien
Olugbenga A. Mokuolu
Caterina I. Fanello
Marie A. Onyamboko
Medizinische Universitat Wien, Zentrum für Pathophysiologie, Infektiologie und Immunologie
Chinese Center for Disease Control and Prevention
Organisation Mondiale de la Santé
University of Maryland
National Institute of Allergy and Infectious Diseases
Armed Forces Research Institute of Medical Sciences, Thailand
University of Maryland School of Medicine
Mahidol University
University of Ilorin
International Centre for Diarrhoeal Disease Research Bangladesh
Nuffield Department of Clinical Medicine
Duke University
Wellcome Sanger Institute
University of Health Sciences
Malaria Research Group and Dev Care Foundation
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)
Defence Services Medical Research Centre
Armed Forces Research Institute of Medical Sciences
WorldWide Antimalarial Resistance Network
Oxford University Clinical Research Unit (OUCRU)
Ministry of Health
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 1-Dec-2019
Citation: Nature Communications. Vol.10, No.1 (2019)
Abstract: © 2019, The Author(s). Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.
ISSN: 20411723
Appears in Collections:Scopus 2019

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