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Title: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
Authors: Hannah C. Slater
Amanda Ross
Ingrid Felger
Natalie E. Hofmann
Leanne Robinson
Jackie Cook
Bronner P. Gonçalves
Anders Björkman
Andre Lin Ouedraogo
Ulrika Morris
Mwinyi Msellem
Cristian Koepfli
Ivo Mueller
Fitsum Tadesse
Endalamaw Gadisa
Smita Das
Gonzalo Domingo
Melissa Kapulu
Janet Midega
Seth Owusu-Agyei
Cécile Nabet
Renaud Piarroux
Ogobara Doumbo
Safiatou Niare Doumbo
Kwadwo Koram
Naomi Lucchi
Venkatachalam Udhayakumar
Jacklin Mosha
Alfred Tiono
Daniel Chandramohan
Roly Gosling
Felista Mwingira
Robert Sauerwein
Eleanor M. Riley
Nicholas J. White
Francois Nosten
Mallika Imwong
Teun Bousema
Chris Drakeley
Lucy C. Okell
University of Health and Allied Sciences, Ghana
Wellcome Trust Centre for Human Genetics
Papua New Guinea Institute of Medical Research
University of Dar Es Salaam
National Institute for Medical Research Tanga
Armauer Hansen Research Institute
Addis Ababa University
London School of Hygiene & Tropical Medicine
PATH Seattle
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
University of Edinburgh, Roslin Institute
University of California, San Francisco
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
Centers for Disease Control and Prevention
University of Notre Dame
Karolinska University Hospital
University of Ghana
Imperial College London
Mahidol University
Nuffield Department of Clinical Medicine
Burnet Institute
Radboud University Nijmegen Medical Centre
Institut Pasteur, Paris
Mnazi Mmoja Hospital
University of Sciences
Institute for Disease Modeling
Centre National de Recherche et de Formation sur le Paludisme
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 1-Dec-2019
Citation: Nature Communications. Vol.10, No.1 (2019)
Abstract: © 2019, The Author(s). Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings.
ISSN: 20411723
Appears in Collections:Scopus 2019

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