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Title: Starvation promotes autophagy-associated maturation of the testis in the giant freshwater prawn, macrobrachium rosenbergii
Authors: Wilairat Kankuan
Chaitip Wanichanon
Federica Morani
Sirorat Thongrod
Rossella Titone
Tanapan Siangcham
Matilde Masini
Michela Novelli
Prasert Sobhon
Ciro Isidoro
Università di Pisa
Mahidol University
Università degli Studi del Piemonte Orientale "Amedeo Avogadro"
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Sep-2019
Citation: Frontiers in Physiology. Vol.10, No.SEP (2019)
Abstract: © 2019 Kankuan, Wanichanon, Morani, Thongrod, Titone, Siangcham, Masini, Novelli, Sobhon and Isidoro. Autophagy is a degradative process of cellular components accomplished through an autophagosomal-lysosomal pathway. It is an evolutionary conserved mechanism present in all eukaryotic cells, and it plays a fundamental role in maintaining tissue homeostasis both in vertebrates and invertebrates. Autophagy accompanies tissue remodeling during organ differentiation. Several autophagy-related genes and proteins show significant upregulations following nutrient shortage (i.e., starvation). In our previous study, we found that in female giant freshwater prawns subjected to a short period of starvation autophagy was up-regulated in consonant with ovarian maturation and oocyte differentiation. Whether and how starvation-induced autophagy impacts on testicular maturation and spermatogenesis of the male prawns remained to be investigated. In this study, we analyzed the effects of starvation on histological and cellular changes in the testis of the giant freshwater prawn Macrobrachium rosenbergii that paralleled the induction of autophagy. Under short starvation condition, the male prawns showed increased gonado-somatic index, increased size, and late stage of maturation of seminiferous tubules, which contained increased number of spermatozoa. Concurrently, the number of autophagy vacuoles and autophagy flux, as monitored by transmission electron microscopy and the autophagic marker LC3, increased in the testicular cells, indicating that a short period of starvation could induce testicular maturation and spermatogenesis in male M. rosenbergii along with modulation of autophagy.
ISSN: 1664042X
Appears in Collections:Scopus 2019

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