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Title: Potential herd protection against plasmodium falciparum infections conferred by mass antimalarial drug administrations
Authors: Daniel M. Parker
Sai Thein Than Tun
Lisa J. White
Ladda Kajeechiwa
May Myo Thwin
Jordi Landier
Victor Chaumeau
Vincent Corbel
Arjen M. Dondorp
Lorenz Von Seidlein
Nicholas J. White
Richard J. Maude
François Nosten
Université de Montpellier
Harvard T.H. Chan School of Public Health
CHU Montpellier
Mahidol University
Nuffield Department of Clinical Medicine
University of California, Irvine
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Apr-2019
Citation: eLife. Vol.8, (2019)
Abstract: © Parker et al. The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts. One solution to this problem is mass drug administration (MDA), with success depending on adequate population participation. Here, we present a detailed spatial and temporal analysis of malaria episodes and asymptomatic infections in four villages undergoing MDA in Myanmar. In this study, individuals from neighborhoods with low MDA adherence had 2.85 times the odds of having a malaria episode post-MDA in comparison to those from high adherence neighborhoods, regardless of individual participation, suggesting a herd effect. High mosquito biting rates, living in a house with someone else with malaria, or having an asymptomatic malaria infection were also predictors of clinical episodes. Spatial clustering of non-adherence to MDA, even in villages with high overall participation, may frustrate elimination efforts.
ISSN: 2050084X
Appears in Collections:Scopus 2019

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