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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/50248
Title: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Authors: Nick Shrine
Anna L. Guyatt
A. Mesut Erzurumluoglu
Victoria E. Jackson
Brian D. Hobbs
Carl A. Melbourne
Chiara Batini
Katherine A. Fawcett
Kijoung Song
Phuwanat Sakornsakolpat
Xingnan Li
Ruth Boxall
Nicola F. Reeve
Ma’en Obeidat
Jing Hua Zhao
Matthias Wielscher
Stefan Weiss
Katherine A. Kentistou
James P. Cook
Benjamin B. Sun
Jian Zhou
Jennie Hui
Stefan Karrasch
Medea Imboden
Sarah E. Harris
Jonathan Marten
Stefan Enroth
Shona M. Kerr
Ida Surakka
Veronique Vitart
Terho Lehtimäki
Richard J. Allen
Per S. Bakke
Terri H. Beaty
Eugene R. Bleecker
Yohan Bossé
Corry Anke Brandsma
Zhengming Chen
James D. Crapo
John Danesh
Dawn L. DeMeo
Frank Dudbridge
Ralf Ewert
Christian Gieger
Amund Gulsvik
Anna L. Hansell
Ke Hao
Joshua D. Hoffman
John E. Hokanson
Georg Homuth
Peter K. Joshi
Philippe Joubert
Claudia Langenberg
Xuan Li
Liming Li
Kuang Lin
Lars Lind
Nicholas Locantore
Jian’an Luan
Anubha Mahajan
Joseph C. Maranville
Alison Murray
David C. Nickle
Richard Packer
Margaret M. Parker
Megan L. Paynton
David J. Porteous
Dmitry Prokopenko
Dandi Qiao
Rajesh Rawal
Heiko Runz
Ian Sayers
Don D. Sin
Blair H. Smith
María Soler Artigas
David Sparrow
Ruth Tal-Singer
Paul R.H.J. Timmers
Maarten Van den Berge
John C. Whittaker
Prescott G. Woodruff
Laura M. Yerges-Armstrong
Olga G. Troyanskaya
Olli T. Raitakari
Mika Kähönen
Ozren Polašek
Ulf Gyllensten
Igor Rudan
Ian J. Deary
Nicole M. Probst-Hensch
Holger Schulz
Alan L. James
James F. Wilson
Beate Stubbe
Eleftheria Zeggini
Marjo Riitta Jarvelin
Nick Wareham
Edwin K. Silverman
Caroline Hayward
Andrew P. Morris
VA Boston Healthcare System
Simons Foundation
Centro de Investigación Biomédica En Red de Salud Mental
National Institute for Health and Welfare
National Jewish Health
Wellcome Trust Centre for Human Genetics
GlaxoSmithKline, USA
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
University of Leicester
Université Laval
University of Western Australia
University of Cambridge
Universitetet i Bergen
Ludwig-Maximilians-Universität München
University of Colorado at Denver Anschutz Medical Campus
Walter and Eliza Hall Institute of Medical Research
University of Edinburgh
University of Oxford
University of Melbourne
Sir Charles Gairdner Hospital
Turun Yliopistollinen Keskussairaala
School of Clinical Medicine
Helmholtz Center Munich German Research Center for Environmental Health
University of California, San Francisco
University of Dundee College of Medicine, Dentistry and Nursing
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
Universitat Autònoma de Barcelona
St Mary's Hospital London
University of Liverpool
GlaxoSmithKline plc.
Brunel University London
Addenbrooke's Hospital
Brigham and Women's Hospital
Oulu University Hospital
Imperial College London
University of Nottingham
Icahn School of Medicine at Mount Sinai
Oulun Yliopisto
Edinburgh Medical School, Medical Research Council Human Genetics Unit
Hospital Universitari Vall d'Hebron
Faculty of Medicine, Siriraj Hospital, Mahidol University
Tampereen Yliopisto
University of Aberdeen School of Medicine
The University of British Columbia
University of Arizona
University of Western Australia Faculty of Medicine and Dentistry
University Hospital of Tampere
Merck & Co., Inc.
Sveučilište u Splitu
Turun yliopisto
Boston University School of Medicine
Johns Hopkins Bloomberg School of Public Health
University of Groningen, University Medical Center Groningen
Wellcome Sanger Institute
Peking University Health Science Center
Uppsala Universitet
Princeton University
Helsingin Yliopisto
Westfälische Wilhelms-Universität Münster
Gossamer Bio
Member of the German Center for Lung Research (DZL)
University Medicine Greifswald
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Mar-2019
Citation: Nature Genetics. Vol.51, No.3 (2019), 481-493
Abstract: © 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function–associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/50248
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062074587&origin=inward
ISSN: 15461718
10614036
Appears in Collections:Scopus 2019

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