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Title: Amides and flavonoids from the fruit and leaf extracts of melodorum siamensis
Authors: Wuttichai Jaidee
Raymond J. Andersen
Miguel A.G. Chavez
Yan A. Wang
Brian O. Patrick
Stephen G. Pyne
Chatchai Muanprasat
Suparerk Borwornpinyo
Surat Laphookhieo
Mae Fah Luang University
Mahidol University
University of Wollongong
The University of British Columbia
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine
Issue Date: 22-Feb-2019
Citation: Journal of Natural Products. Vol.82, No.2 (2019), 283-292
Abstract: © 2019 American Chemical Society and American Society of Pharmacognosy. Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and 2 (er 1.1:1) were scalemic and were resolved to yield -1 and (+)-1 and -2 and (+)-2, respectively. The absolute configurations of these compounds were determined from experimental and calculated ECD data. The structures and configurations of -2 and (+)-8 were identified by single-crystal X-ray diffraction analysis. Compound 11 showed nuclear factor-B inhibitory effects (IC 50 = 9 μM) in a pancreatic β cell line (MIN-6 cells).
ISSN: 15206025
Appears in Collections:Scopus 2019

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