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Title: | Amides and flavonoids from the fruit and leaf extracts of melodorum siamensis |
Authors: | Wuttichai Jaidee Raymond J. Andersen Miguel A.G. Chavez Yan A. Wang Brian O. Patrick Stephen G. Pyne Chatchai Muanprasat Suparerk Borwornpinyo Surat Laphookhieo Mae Fah Luang University Mahidol University University of Wollongong The University of British Columbia |
Keywords: | Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine |
Issue Date: | 22-Feb-2019 |
Citation: | Journal of Natural Products. Vol.82, No.2 (2019), 283-292 |
Abstract: | © 2019 American Chemical Society and American Society of Pharmacognosy. Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and 2 (er 1.1:1) were scalemic and were resolved to yield -1 and (+)-1 and -2 and (+)-2, respectively. The absolute configurations of these compounds were determined from experimental and calculated ECD data. The structures and configurations of -2 and (+)-8 were identified by single-crystal X-ray diffraction analysis. Compound 11 showed nuclear factor-B inhibitory effects (IC 50 = 9 μM) in a pancreatic β cell line (MIN-6 cells). |
URI: | http://repository.li.mahidol.ac.th/dspace/handle/123456789/50251 |
metadata.dc.identifier.url: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061291220&origin=inward |
ISSN: | 15206025 01633864 |
Appears in Collections: | Scopus 2019 |
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