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dc.contributor.authorWuttichai Jaideeen_US
dc.contributor.authorRaymond J. Andersenen_US
dc.contributor.authorMiguel A.G. Chavezen_US
dc.contributor.authorYan A. Wangen_US
dc.contributor.authorBrian O. Patricken_US
dc.contributor.authorStephen G. Pyneen_US
dc.contributor.authorChatchai Muanprasaten_US
dc.contributor.authorSuparerk Borwornpinyoen_US
dc.contributor.authorSurat Laphookhieoen_US
dc.contributor.otherMae Fah Luang Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Wollongongen_US
dc.contributor.otherThe University of British Columbiaen_US
dc.identifier.citationJournal of Natural Products. Vol.82, No.2 (2019), 283-292en_US
dc.description.abstract© 2019 American Chemical Society and American Society of Pharmacognosy. Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and 2 (er 1.1:1) were scalemic and were resolved to yield -1 and (+)-1 and -2 and (+)-2, respectively. The absolute configurations of these compounds were determined from experimental and calculated ECD data. The structures and configurations of -2 and (+)-8 were identified by single-crystal X-ray diffraction analysis. Compound 11 showed nuclear factor-B inhibitory effects (IC 50 = 9 μM) in a pancreatic β cell line (MIN-6 cells).en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAmides and flavonoids from the fruit and leaf extracts of melodorum siamensisen_US
Appears in Collections:Scopus 2019

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