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Title: Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice
Authors: Vanessa Salazar
Brett W. Jagger
Juthathip Mongkolsapaya
Katherine E. Burgomaster
Wanwisa Dejnirattisai
Emma S. Winkler
Estefania Fernandez
Christopher A. Nelson
Daved H. Fremont
Theodore C. Pierson
James E. Crowe
Gavin R. Screaton
Michael S. Diamond
Vanderbilt University Medical Center
Washington University School of Medicine in St. Louis
National Institute of Allergy and Infectious Diseases
Faculty of Medicine, Siriraj Hospital, Mahidol University
Nuffield Department of Clinical Medicine
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 5-Feb-2019
Citation: Cell Reports. Vol.26, No.6 (2019), 1585-1597.e4
Abstract: © 2019 The Author(s) Salazar et al. show that SPOV, the flavivirus most closely related to ZIKV, infects mice when type I interferon signaling is blocked. SPOV causes ankle swelling and infection in the foot, which is more typical of alphaviruses. Human antibodies from ZIKV or DENV subjects protect against lethal SPOV challenge.
ISSN: 22111247
Appears in Collections:Scopus 2019

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