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Title: ’Candidatus Ornithobacterium hominis’: Insights gained from draft genomes obtained from nasopharyngeal swabs
Authors: Susannah J. Salter
Paul Scott
Andrew J. Page
Alan Tracey
Marcus C. de Goffau
Claire Cormie
Bernardo Ochoa-Montaño
Clare L. Ling
Jiraporn Tangmanakit
Paul Turner
Julian Parkhill
University of Cambridge
Quadram Institute Bioscience
Mahidol University
Nuffield Department of Clinical Medicine
Wellcome Sanger Institute
Illumina Cambridge Ltd.
Angkor Hospital for Children
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Feb-2019
Citation: Microbial Genomics. Vol.5, No.2 (2019)
Abstract: © 2019 The Authors. ‘Candidatus Ornithobacterium hominis’ represents a new member of the Flavobacteriaceae detected in 16S rRNA gene surveys of people from South-East Asia, Africa and Australia. It frequently colonizes the infant nasopharynx at high proportional abundance, and we demonstrate its presence in 42 % of nasopharyngeal swabs from 12-month-old children in the Maela refugee camp in Thailand. The species, a Gram-negative bacillus, has not yet been cultured, but the cells can be identified in mixed samples by fluorescent hybridization. Here, we report seven genomes assembled from metagenomic data, two to improved draft standard. The genomes are approximately 1.9 Mb, sharing 62 % average amino acid identity with the only other member of the genus, the bird pathogen Ornithobacterium rhinotracheale. The draft genomes encode multiple antibiotic-resistance genes, competition factors, Flavobacterium johnsoniae-like gliding motility genes and a homologue of the Pasteurella multocida mitogenic toxin. Intra-and inter-host genome comparison suggests that colonization with this bacterium is both persistent and strain exclusive.
ISSN: 20575858
Appears in Collections:Scopus 2019

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