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dc.contributor.authorBilal Haider Abbasien_US
dc.contributor.authorAisha Siddiquahen_US
dc.contributor.authorDuangjai Tungmunnithumen_US
dc.contributor.authorShankhamala Boseen_US
dc.contributor.authorMuhammad Younasen_US
dc.contributor.authorLaurine Garrosen_US
dc.contributor.authorSamantha Droueten_US
dc.contributor.authorNathalie Giglioli-Guivarc’hen_US
dc.contributor.authorChristophe Hanoen_US
dc.contributor.otherQuaid-i-Azam Universityen_US
dc.contributor.otherUniversité de Toursen_US
dc.contributor.otherUniversite d'Orleansen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCNRS Centre National de la Recherche Scientifiqueen_US
dc.identifier.citationInternational Journal of Molecular Sciences. Vol.20, No.2 (2019)en_US
dc.description.abstract© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Isodon rugosus (Wall. ex Benth.) Codd accumulates large amounts of phenolics and pentacyclic triterpenes. The present study deals with the in vitro callus induction from stem and leaf explants of I. rugosus under various plant growth regulators (PGRs) for the production of antioxidant and anti-ageing compounds. Among all the tested PGRs, thidiazuron (TDZ) used alone or in conjunction with α-napthalene acetic acid (NAA) induced highest callogenesis in stem-derived explants, as compared to leaf-derived explants. Stem-derived callus culture displayed maximum total phenolic content and antioxidant activity under optimum hormonal combination (3.0 mg/L TDZ + 1.0 mg/L NAA). HPLC analysis revealed the presence of plectranthoic acid (373.92 µg/g DW), oleanolic acid (287.58 µg/g DW), betulinic acid (90.51 µg/g DW), caffeic acid (91.71 µg/g DW), and rosmarinic acid (1732.61 µg/g DW). Complete antioxidant and anti-aging potential of extracts with very contrasting phytochemical profiles were investigated. Correlation analyses revealed rosmarinic acid as the main contributor for antioxidant activity and anti-aging hyaluronidase, advance glycation end-products inhibitions and SIRT1 activation, whereas, pentacyclic triterpenoids were correlated with elastase, collagenase, and tyrosinase inhibitions. Altogether, these results clearly evidenced the great valorization potential of I. rugosus calli for the production of antioxidant and anti-aging bioactive extracts for cosmetic applications.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectComputer Scienceen_US
dc.titleIsodon rugosus (Wall. ex Benth.) codd in vitro cultures: Establishment, phytochemical characterization and in vitro antioxidant and anti-aging activitiesen_US
Appears in Collections:Scopus 2019

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