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Title: Protective effects of diarylpropionitrile against hydrogen peroxide-induced damage in human neuroblastoma SH-SY5Y cells
Authors: Nopparat Suthprasertporn
Nirut Suwanna
Wipawan Thangnipon
Kasetsart University, Kamphaeng Saen Campus
Mahidol University
Keywords: Chemical Engineering;Environmental Science;Medicine
Issue Date: 1-Jan-2019
Citation: Drug and Chemical Toxicology. (2019)
Abstract: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Oxidative stress is implicated in pathogenesis of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. The study demonstrates diarylpropionitrile (DPN), an antioxidant selective agonist of estrogen receptor β, protected human neuroblastoma SH-SY5Y cells against H2O2-induced toxicity by attenuating production of reactive oxygen species, apoptosis, autophagy, NF-κB activation, MAPK p38, JNK and ERK 1/2 signaling pathways, and β-site amyloid precursor protein cleaving enzyme level, but, interestingly, stimulating Akt pathway. These findings indicate the important potential of DPN to ameliorate oxidative stress-associated damage in neurodegenerative disorders.
ISSN: 15256014
Appears in Collections:Scopus 2019

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