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Title: Boronic acid Functionalized Guided Mode Resonance Sensor for HbA1c Detection
Authors: Boonrasri Seeleang
Songpol Ongwattanakul
Chamras Promptmas
Sakoolkan Boonruang
Waleed S. Mohammed
Romuald Jolivot
Mahidol University
Bangkok University
Thailand National Electronics and Computer Technology Center
Keywords: Computer Science;Engineering
Issue Date: 10-Jan-2019
Citation: BMEiCON 2018 - 11th Biomedical Engineering International Conference. (2019)
Abstract: © 2018 IEEE. An alternative optical label-free sensor, Guided Mode Resonance (GMR), is demonstrated in this paper for detection of glycated hemoglobin (HbA1c). The GMR sensor surface is modified by cross-linking with 3-amino phenylboronic acids (3-APBA) using 3-(glycidyloxypropyl) trimethoxysilane (GOPTMS). 3-APBA provides a specific interaction with HbA1c under alkaline condition. The sensing scheme is performed by tracking a peak resonance in a reflection spectrum. That relies on changes in refractive index on the sensor's surface. Percent of HbA1c in total hemoglobin can be estimated using a ration of resonance shift due to absorbed HbA1c and the shift from changes in a bulk refractive index of a whole blood (Δλ HbA1c /Δλ TotalHb ). In the measurement, Lypochek diabetes controls having 5.1% (range: 4.6-5.6% measured by HPLC) and 9.5% (range: 8.5-10.4% measured by HPLC) HbA1c are used. The results from a resonance shift ration is linearly proportional to the measurement from the HPLC standard method with a precision of 7.71-20.77% CV. This guarantees boronate-modified GMR affinity sensor for the monitoring of glycemic status in diabetes management.
Appears in Collections:Scopus 2019

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